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Article

GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.

Human molecular genetics - 15 Nov 2011

Benyamin Beben, Middelberg Rita P, Lind Penelope A, Valle Anne M, Gordon Scott, Nyholt Dale R, Medland Sarah E, Henders Anjali K, Heath Andrew C, Madden Pamela A F, Visscher Peter M, O'Connor Daniel T, Montgomery Grant W, Martin Nicholas G, Whitfield John B

Abstract excerpt

Serum butyrylcholinesterase (BCHE) activity is associated with obesity, blood pressure and biomarkers of cardiovascular and diabetes risk. We have conducted a genome-wide association scan to discover genetic variants affecting BCHE activity, and to clarify whether the associations between BCHE activity and cardiometabolic risk factors are caused by variation in BCHE or whether BCHE variation is secondary to the...

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Share to Adaptor Proteins, Signal Transducing
Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21862451
DOI: 10.1093/hmg/ddr375
PMCID: PMC3196893

Genes

BCHE
ABI2
FTO
GCKR
RAPH1
RNPEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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