Article
Hepatic energy metabolism in a family with a glucokinase gene mutation and dysglycemia.
Diabetes research and clinical practice - 1 Mar 2022
Bódis Kálmán, Knebel Birgit, Nowotny Bettina, Bobrov Pavel, Kupriyanova Yuliya, Zaharia Oana-Patricia, Karusheva Yanislava, Schön Martin, Wolkersdorfer Martin, Burkart Volker, Al-Hasani Hadi, Markgraf Daniel, Müssig Karsten, Roden Michael, Szendroedi Julia
Abstract excerpt
Carriers heterozygous for the D124N (c.370, GAC > AAC in exon 4) variant of GCK not only exhibit reduced insulin-secretion, but also impaired adipose insulin sensitivity, which may shift fatty acids towards the liver. This could contribute to increased hepatic lipid-accumulation and alterations of liver energy metabolism resulting in dysglycemia. ClinicalTrial.gov registration no: NCT01055093.
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