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Article

Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis

12 Apr 2011

Abstract excerpt

The human kinome includes Ror1, a poorly characterized orphan receptor. Here we report the findings of an investigation of Ror1 contributions to cancer, undertaken through an integrated screening of 43 cancer cell lines where we measured protein expression, tyrosine phosphorylation, and growth response following RNAi-mediated Ror1 suppression. Ror1 was expressed in approximately 75% of the cancer cell lines...

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PMID: 21487037
DOI: 10.1158/0008-5472.can-10-2662

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