Article
The structure of the cataract-causing P23T mutant of human gammaD-crystallin exhibits distinctive local conformational and dynamic changes.
Biochemistry - 31 Mar 2009
Jung Jinwon, Byeon In-Ja L, Wang Yongting, King Jonathan, Gronenborn Angela M
Abstract excerpt
Crystallins are major proteins of the eye lens and essential for lens transparency. Mutations and aging of crystallins cause cataracts, the predominant cause of blindness in the world. In human gammaD-crystallin, the P23T mutant is associated with congenital cataracts. Until now, no atomic structural information has been available for this variant. Biophysical analyses of this mutant protein have revealed...
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