Article
Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by NF-kappa B binding motifs.
The EMBO journal - 1 Dec 1990
Williams J L, Garcia J, Harrich D, Pearson L, Wu F, Gaynor R
Abstract excerpt
A primary site of infection by human adenoviruses is lymphoid cells. However, analysis of the viral control elements and the cellular factors that regulate adenoviral gene expression in lymphocytes has not been reported. The adenovirus early region 3 (ES) gene products are involved in the maintenance of viral persistence by complexing with the class I MHC antigens, thus preventing their cell surface expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.