Two distinct upstream regulatory domains containing multicopy cellular transcription factor binding sites provide basal repression and inducible enhancer characteristics to the immediate-early IES (US3) promoter from human cytomegalovirus.

Abstract excerpt

The US3 gene of human cytomegalovirus (HCMV) is expressed at immediate-early (IE) times in permissive HF cells, but not in nonpermissive rodent cells, and encodes several proteins that have been reported to have regulatory characteristics, although they are dispensable for growth in cell culture....

Topics

• Animals
• Base Sequence
• Binding Sites
• Cell Line
• Cytomegalovirus
• Enhancer Elements, Genetic
• Gene Expression Regulation, Viral
• Genes, Immediate-Early
• Humans
• Molecular Sequence Data
• Mutation
• NF-kappa B
• Promoter Regions, Genetic
• Virus Integration