Article
Synthesis of β-(1→6)-linked N-acetyl-D-glucosamine oligosaccharide substrates and their hydrolysis by Dispersin B.
Carbohydrate research - 6 Sept 2011
Fekete Anikó, Borbás Anikó, Gyémánt Gyöngyi, Kandra Lili, Fazekas Erika, Ramasubbu Narayanan, Antus Sándor
Abstract excerpt
Dispersin B (DspB) from Aggregatibacter actinomycetemcomitans is a β-hexosaminidase exhibiting biofilm detachment activity. A series of β-(1→6)-linked N-acetyl-D-glucosamine thiophenyl glycosides with degree of polymerisation (DP) of 2, 3, 4 and 5 were synthesized, and substrate specificity of DspB was studied on the obtained oligosaccharides. For oligomer synthesis a 1+2, 2+2, 1+4 coupling strategy was applied,...
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