Article
An Inactive Dispersin B Probe for Monitoring PNAG Production in Biofilm Formation.
ACS chemical biology - 15 May 2020
Eddenden Alexander, Kitova Elena N, Klassen John S, Nitz Mark
Abstract excerpt
The bacterial exopolysaccharide poly-β-1,6-N-acetylglucosamine is a major extracellular matrix component in biofilms of both Gram-positive and Gram-negative organisms. We have leveraged the specificity of the biofilm-dispersing glycoside hydrolase Dispersin B (DspB) to generate a probe (Dispersin B PNAG probe, DiPP) for monitoring PNAG production and localization during biofilm formation. Mutation of the active...
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