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Article

The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.

Structure (London, England : 1993) - 13 Apr 2011

Yeh Tzu-Lan, Lee Chih-Yung S, Amzel L Mario, Espenshade Peter J, Bianchet Mario A

Abstract excerpt

Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth. Nro1 regulates the stability of the N-terminal transcription factor domain of Sre1 (Sre1N) by inhibiting the action of the prolyl 4-hydroxylase-like Ofd1 in an oxygen-dependent manner. The crystal structure of Nro1...

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Identifiers

PMID: 21481773
DOI: 10.1016/j.str.2011.01.017
PMCID: PMC3086001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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