Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2.

Cell - 30 Nov 1990

Chang F, Herskowitz I

Abstract excerpt

alpha factor is a negative growth factor and differentiation factor that induces G1 arrest and increases transcription of mating genes in S. cerevisiae a cells. We have identified a gene, FAR1 (for "factor arrest"), which is necessary for cell cycle arrest but not for other responses to alpha factor: far1- mutants are insensitive to arrest despite having an intact signal transduction pathway. FAR1 is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Genes, Fungal

Share to Genotype

Share to Molecular Sequence Data

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 2147873
DOI: 10.1016/0092-8674(90)90503-7

Genes

FAR1
CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2.PMID 2147873Read ↗

Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway.Semantic proximity Read ↗

Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae.Semantic proximity Read ↗

G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle.Semantic proximity Read ↗

Cyclin-specific START events and the G1-phase specificity of arrest by mating factor in budding yeast.Semantic proximity Read ↗

FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone.Semantic proximity Read ↗

The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle.Semantic proximity Read ↗

POG1, a novel yeast gene, promotes recovery from pheromone arrest via the G1 cyclin CLN2.Semantic proximity Read ↗

Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p.Semantic proximity Read ↗

FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins.Semantic proximity Read ↗

Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.Semantic proximity Read ↗

The Sda1 protein is required for passage through start.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.