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Article

Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p.

Genetics - 1 Mar 1999

Cherkasova V, Lyons D M, Elion E A

Abstract excerpt

In Saccharomyces cerevisiae, mating pheromones activate two MAP kinases (MAPKs), Fus3p and Kss1p, to induce G1 arrest prior to mating. Fus3p is known to promote G1 arrest by activating Far1p, which inhibits three Clnp/Cdc28p kinases. To analyze the contribution of Fus3p and Kss1p to G1 arrest that is independent of Far1p, we constructed far1 CLN strains that undergo G1 arrest from increased activation of the...

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Identifiers

PMID: 10049917
DOI: 10.1093/genetics/151.3.989
PMCID: PMC1460542

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p.PMID 10049917Read ↗

Identification and characterization of FAR3, a gene required for pheromone-mediated G1 arrest in Saccharomyces cerevisiae.Semantic proximity Read ↗

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation.Semantic proximity Read ↗

far4, far5, and far6 define three genes required for efficient activation of MAPKs Fus3 and Kss1 and accumulation of glycogen.Semantic proximity Read ↗

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.Semantic proximity Read ↗

Saccharomyces cerevisiae Mpt5p interacts with Sst2p and plays roles in pheromone sensitivity and recovery from pheromone arrest.Semantic proximity Read ↗

Mitogen-activated protein kinase (MAPK) dynamics determine cell fate in the yeast mating response.Semantic proximity Read ↗

Nuclear relocation of Kss1 contributes to the specificity of the mating response.Semantic proximity Read ↗

Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating.Semantic proximity Read ↗

Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins.Semantic proximity Read ↗

Saccharomyces cerevisiae Ste5 is important for induction and substrate specificity of Fus3 MAP kinase in the pheromone signaling pathway.Semantic proximity Read ↗

Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae.Semantic proximity Read ↗

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