G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Start in the yeast cell cycle.

Abstract excerpt

Transcriptional induction by the mating pheromone alpha-factor was monitored at different stages of the yeast cell cycle. G2/M-phase and pre-Start cells showed strong FUS1 mRNA induction, whereas in post-Start cells the signaling was reduced significantly. This reduction in signaling activity in post-Start cells was correlated with the presence of CLN1 or CLN2 transcripts and was not observed in synchronized...

Topics

• Base Sequence
• CDC28 Protein Kinase, S cerevisiae
• Cell Cycle
• Cell Cycle Proteins
• Cyclin-Dependent Kinase Inhibitor Proteins
• Cyclins
• Fungal Proteins
• G1 Phase
• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gq-G11