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Article

Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression.

Atherosclerosis - 1 Apr 2014

Serrano Ramon L, Yu Weifang, Terkeltaub Robert

Abstract excerpt

OBJECTIVE: Bi-allelic function-inactivating ENPP1 mutations cause artery media calcification (AMC) with associated severe myointimal hyperplasia in generalized arterial calcification of infancy (GACI), whereas mono-allelic ENPP1 deficiency is phenotypically normal. Here, we tested if ENPP1 deficiency promotes abnormal vascular smooth muscle cell (VSMC)-driven responses to injury, with or without calcification....

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Source

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Identifiers

PMID: 24530784
DOI: 10.1016/j.atherosclerosis.2014.01.003
PMCID: PMC4386864

Genes

ENPP1
EBP
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Mono-allelic and bi-allelic ENPP1 deficiency promote post-injury neointimal hyperplasia associated with increased C/EBP homologous protein expression.PMID 24530784Read ↗

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