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Article

The BRAF(V600E) inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells.

Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2015

Jenkins Molly H, Croteau Walburga, Mullins David W, Brinckerhoff Constance E

Abstract excerpt

Vertical growth phase (VGP) melanoma is frequently metastatic, a process mediated by changes in gene expression, which are directed by signal transduction pathways in the tumor cells. A prominent signaling pathway is the Ras-Raf-Mek-Erk MAPK pathway, which increases expression of genes that promo...

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Identifiers

PMID: 25989506
DOI: 10.1016/j.matbio.2015.05.007
PMCID: PMC5048745

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25989506-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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