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Article

Animal models of cardiac fibrosis.

Methods in molecular medicine - 1 Jan 2005

Sun Yao, Weber Karl T

Abstract excerpt

A collagen network, composed largely of type I and III fibrillar collagens, is found in the heart's interstitial space. This network has multiple functions, including the preservation of tissue architecture and chamber geometry. Given its tensile strength, type I collagen is a major determinant of tissue stiffness. Its disproportionate accumulation, expressed in morphological terms as tissue fibrosis, increases...

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Identifiers

PMID: 16130232
DOI: 10.1385/1-59259-940-0:273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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