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Article

Reduced H3K27me3 levels in diffuse gliomas: association with 1p/19q codeletion and difference from H3K27me3 loss in malignant peripheral nerve sheath tumors.

Brain tumor pathology - 1 Jan 2021

Kitahama Keiichiro, Iijima Shohei, Sumiishi Ayumi, Hayashi Akimasa, Nagahama Kiyotaka, Saito Kuniaki, Sasaki Nobuyoshi, Kobayashi Keiichi, Shimizu Saki, Nagane Motoo, Shibahara Junji

Abstract excerpt

Trimethylation of histone H3 at lysine 27 (H3K27me3) acts as a transcriptional repressor of target genes. Recent immunohistochemical studies have reported a loss of H3K27me3 modification in diffuse (especially 1p/19q-codeleted) gliomas. However, we did not observe H3K27me3 loss in diffuse gliomas using routine immunostaining conditions for the detection of H3K27me3 loss in malignant peripheral nerve sheath tumors...

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PMID: 32989606
DOI: 10.1007/s10014-020-00382-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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