Article
Alterations in the RB Pathway With Inactivation of RB1 Characterize Glioblastomas With a Primitive Neuronal Component.
Journal of neuropathology and experimental neurology - 29 Dec 2021
Chkheidze Rati, Raisanen Jack, Gagan Jeffrey, Richardson Timothy E, Pinho Marco C, Raj Karuna, Achilleos Michael, Slepicka Chenelle, White Charles L, Evers Bret M, Patel Toral R, Malter James S, Hatanpaa Kimmo J
Abstract excerpt
A primitive neuronal component is a feature of some glioblastomas but defining molecular alterations of this histologic variant remains uncertain. We performed next-generation sequencing of 1500 tumor related genes on tissue from 9 patients with glioblastoma with a primitive component (G/PN) and analyzed 27 similar cases from the Cancer Genome Atlas (TCGA) dataset. Alterations in the RB pathway were identified in...
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