A Study of the Coevolutionary Patterns Operating within the env Gene of the HIV-1 Group M Subtypes

Abstract excerpt

The env gene of human immunodeficiency virus (HIV) is a functionally important gene responsible for the production of protein products (gp120 and gp41) involved in host cell recognition, binding, and entry. This occurs through a complex and, as yet, not fully understood process of protein-protein interaction and within and between protein functional communication. Exposure on the surface of active HIV virions...

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