Article
Polygenic susceptibility to prostate and breast cancer: implications for personalised screening.
British journal of cancer - 10 May 2011
Pashayan N, Duffy S W, Chowdhury S, Dent T, Burton H, Neal D E, Easton D F, Eeles R, Pharoah P
Abstract excerpt
BACKGROUND: We modelled the efficiency of a personalised approach to screening for prostate and breast cancer based on age and polygenic risk-profile compared with the standard approach based on age alone. METHODS: We compared the number of cases potentially detectable by screening in a population undergoing personalised screening with a population undergoing screening based on age alone. Polygenic disease risk...
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