Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma.

doi:10.1200/JCO.2008.19.1916

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2009

Anguiano Ariel, Tuchman Sascha A, Acharya Chaitanya, Salter Kelly, Gasparetto Cristina, Zhan Fenghuang, Dhodapkar Madhav, Nevins Joseph, Barlogie Bart, Shaughnessy John D, Potti Anil

Abstract excerpt

PURPOSE: Monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) comprise heterogeneous disorders with incompletely understood molecular defects and variable clinical features. We performed gene expression profiling (GEP) with microarray data to better dissect the molecular phenotypes, sensitivity to particular chemotherapeutic agents, and prognoses of these diseases. METHODS: Using...

Topics

Adult
Aged
Antineoplastic Agents
Biomarkers, Tumor
Chromosomal Instability
Cluster Analysis
Databases as Topic
Disease-Free Survival
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Gene Expression Regulation, Neoplastic

Genotype

Humans

Kaplan-Meier Estimate

Male

Middle Aged

Multiple Myeloma

Neoplasm Staging

Source

Open in PubMed Open full text

Identifiers

PMID: 19636021
DOI: 10.1200/JCO.2008.19.1916
PMCID: PMC4881369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma.PMID 19636021Read ↗

Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosisSemantic proximity Read ↗

Gene expression profiling of plasma cell dyscrasias reveals molecular patterns associated with distinct IGH translocations in multiple myeloma.Semantic proximity Read ↗

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cellsSemantic proximity Read ↗

A Comprehensive Review of the Genomics of Multiple Myeloma: Evolutionary Trajectories, Gene Expression Profiling, and Emerging Therapeutics.Semantic proximity Read ↗

Gene Expression Profiles in Myeloma: Ready for the Real World?Semantic proximity Read ↗

Insights into the multistep transformation of MGUS to myeloma using microarray expression analysisSemantic proximity Read ↗

Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profilingSemantic proximity Read ↗

Revised International Staging System (R-ISS) stage-dependent analysis uncovers oncogenes and potential immunotherapeutic targets in multiple myelomaSemantic proximity Read ↗

Exploring the Molecular Mechanisms and Shared Genetic Characteristics of Monoclonal Gammopathy of Undetermined Significance and Multiple MyelomaSemantic proximity Read ↗

The molecular classification of multiple myelomaSemantic proximity Read ↗

The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myelomaSemantic proximity Read ↗

Genome-Wide Identification of Potential Biomarkers in Multiple Myeloma Using Meta-Analysis of mRNA and miRNA Expression DataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.