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Article

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector Tropism

6 Apr 2011

Abstract excerpt

Oncolytic measles viruses (MV) derived from the live attenuated vaccine strain have been engineered for increased tumor-cell specificity, and are currently under investigation in clinical trials including a phase I study for glioblastoma multiforme (GBM). Recent preclinical studies have shown that the cellular tropism of several viruses can be controlled by inserting microRNA-target sequences into their genomes,...

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PMID: 21468006
DOI: 10.1038/mt.2011.55

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