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Article

Enhanced Control of Oncolytic Measles Virus Using MicroRNA Target Sites

11 Apr 2018

Abstract excerpt

Measles viruses derived from the live-attenuated Edmonton-B vaccine lineage are currently investigated as novel anti-cancer therapeutics. In this context, tumor specificity and oncolytic potency are key determinants of the therapeutic index. Here, we describe a systematic and comprehensive analysis of a recently developed post-entry targeting strategy based on the incorporation of microRNA target sites (miRTS)...

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PMID: 29988512
DOI: 10.1016/j.omto.2018.04.002

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