Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor Efficacy

8 Mar 2011

Abstract excerpt

Vaccinia virus, once widely used for smallpox vaccine, has recently been engineered and used as an oncolytic virus for cancer virotherapy. Their replication has been restricted to tumors by disrupting viral genes and complementing them with products that are found specifically in tumor cells. Here, we show that microRNA (miRNA) regulation also enables tumor-specific viral replication by altering the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Plant Virus Research Studies
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21386827
DOI: 10.1038/mt.2011.36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor EfficacyPMID 21386827Read ↗

miRNA-Mediated Mechanisms in the Generation of Effective and Safe Oncolytic VirusesSemantic proximity Read ↗

Vaccinia as a vector for gene deliverySemantic proximity Read ↗

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector TropismSemantic proximity Read ↗

Oncolytic Vaccinia Virus Disrupts Tumor-Associated Vasculature in HumansSemantic proximity Read ↗

Deletion of F4L (ribonucleotide reductase) in vaccinia virus produces a selective oncolytic virus and promotes anti‐tumor immunity with superior safety in bladder cancer modelsSemantic proximity Read ↗

Vaccinia as a vector for tumor-directed gene therapy: biodistribution of a thymidine kinase-deleted mutant.Semantic proximity Read ↗

Characterization of Morreton Virus (MORV) as a Novel Oncolytic Virotherapy Platform for Liver CancersSemantic proximity Read ↗

Oncolytic PoxvirusesSemantic proximity Read ↗

First-in-man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread, and Antitumor ActivitySemantic proximity Read ↗

Therapeutic Applications for Oncolytic Self-Replicating RNA VirusesSemantic proximity Read ↗

Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs.Semantic proximity Read ↗

Virus-encoded miR-155 ortholog is an important potential regulator but not essential for the development of lymphomas induced by very virulent Marek's disease virusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.