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Article

Attenuation of Vesicular Stomatitis Virus Encephalitis through MicroRNA Targeting

12 Nov 2009

Abstract excerpt

Vesicular stomatitis virus (VSV) has long been regarded as a promising recombinant vaccine platform and oncolytic agent but has not yet been tested in humans because it causes encephalomyelitis in rodents and primates. Recent studies have shown that specific tropisms of several viruses could be eliminated by engineering microRNA target sequences into their genomes, thereby inhibiting spread in tissues expressing...

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Identifiers

PMID: 19906911
DOI: 10.1128/jvi.01788-09

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