Article
N-glycan-defective breast cancer cells induce a phenotypic switch in polarization of bone marrow-derived macrophages.
Clinical and investigative medicine. Medecine clinique et experimentale - 1 Apr 2011
Chen Haidan, Cai Huili, Chen Liang, Wu Xianglei, Li Dongqing
Abstract excerpt
PURPOSE: To investigate the effect of N-glycan-defective mammary adenocarcinoma cells on the polarization of macrophages. METHODS: N-glycan-defective breast cancer cells (MA782 cells) were prepared by swainsonine (SW) treatment and the cytotoxicity of SW to MA782 cells was evaluated using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The N-glycan-defective MA782 cells were...
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