Article
High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype.
Neoplasia (New York, N.Y.) - 1 Jun 2025
Bryan Allyn, Isbell Madison, Pingali Pavani, May Lauren, Shah Syed A, Khader Adam, Galabow Andrea, Lorenz Madelyn, Koblinski Jennifer, Lee Won Sok, Martin Rebecca K, Patel Bhaumik, Landry Joseph, Neuwelt Alex
Abstract excerpt
OBJECTIVE: High dose acetaminophen (AAP) has demonstrated promising results in early phase clinical trials for treatment of advanced malignancies. When administered concurrently with the CYP2E1 inhibitor fomepizole, AAP can be dose-escalated 100-fold relative to standard dosing without liver toxicity and without compromising anti-tumor activity. METHODS AND ANALYSIS: The current study used a 23-plex flow...
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