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Article

Genetics of breast cancer: a topic in evolution.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2015

Shiovitz S, Korde L A

Abstract excerpt

A hereditary predisposition to breast cancer significantly influences screening and follow-up recommendations for high-risk women. However, in patients with a suggestive personal and/or family history, a specific predisposing gene is identified in <30% of cases. Up to 25% of hereditary cases are due to a mutation in one of the few identified rare, but highly penetrant genes (BRCA1, BRCA2, PTEN, TP53, CDH1, and...

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Topics

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Share to Breast Neoplasms
Share to BRIP1 gene
Share to PALB2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to STK11 gene

Share to Genetic Predisposition to Disease

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Share to Neoplasm Proteins

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 25605744
DOI: 10.1093/annonc/mdv022
PMCID: PMC4478970

Genes

ATM
BRCA1
BRCA2
BRIP1
CDH1
CHEK2
PALB2
PTEN
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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