Article
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion.
Cancer research - 1 Apr 2011
Dirat Béatrice, Bochet Ludivine, Dabek Marta, Daviaud Danièle, Dauvillier Stéphanie, Majed Bilal, Wang Yuan Yuan, Meulle Aline, Salles Bernard, Le Gonidec Sophie, Garrido Ignacio, Escourrou Ghislaine, Valet Philippe, Muller Catherine
Abstract excerpt
Early local tumor invasion in breast cancer results in a likely encounter between cancer cells and mature adipocytes, but the role of these fat cells in tumor progression remains unclear. We show that murine and human tumor cells cocultivated with mature adipocytes exhibit increased invasive capacities in vitro and in vivo, using an original two-dimensional coculture system. Likewise, adipocytes cultivated with...
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