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Article

Taming lupus-a new understanding of pathogenesis is leading to clinical advances.

Nature medicine - 6 Jun 2012

Liu Zheng, Davidson Anne

Abstract excerpt

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and damage to multiple organ systems. Over the years, patients with SLE have been managed largely with empiric immunosuppressive therapies, which are associated with substantial toxicities and do not always provide adequate control of the...

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Identifiers

PMID: 22674006
DOI: 10.1038/nm.2752
PMCID: PMC3607103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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