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Article

Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis.

International journal of oncology - 1 Jun 2011

Chien Wenwen, O'Kelly James, Lu Daning, Leiter Amanda, Sohn Julia, Yin Dong, Karlan Beth, Vadgama Jay, Lyons Karen M, Koeffler H Phillip

Abstract excerpt

Connective tissue growth factor (CTGF/CCN2) belongs to the CCN family of matricellular proteins, comprising Cyr61, CTGF, NovH and WISP1-3. The CCN proteins contain an N-terminal signal peptide followed by four conserved domains sharing sequence similarities with the insulin-like growth factor binding proteins, von Willebrand factor type C repeat, thrombospondin type 1 repeat, and a C-terminal growth factor...

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Source

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Identifiers

PMID: 21455569
DOI: 10.3892/ijo.2011.985
PMCID: PMC3711677

Genes

CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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