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Article

Domain and Functional Analysis of a Novel Breast Tumor Suppressor Protein, SCUBE2

8 Jun 2011

Abstract excerpt

Signal peptide CUB (complement proteins C1r/C1s, Uegf, and Bmp 1)-EGF domain-containing protein 2 (SCUBE2) is a secreted, membrane-associated multidomain protein composed of five recognizable motifs: an NH(2)-terminal signal peptide sequence, nine copies of epidermal growth factor (EGF)-like repeats, a spacer region, three cysteine-rich repeats, and one CUB domain at the COOH terminus. Our previous clinical study...

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PMID: 21652720
DOI: 10.1074/jbc.m111.244418

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