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Article

The role of connective tissue growth factor, a multifunctional matricellular protein, in fibroblast biology

1 Nov 2003

Abstract excerpt

Connective tissue growth factor (CTGF, CCN2), a member of the CCN family of proteins, is a cysteine-rich proadhesive matricellular protein that plays an essential role in the formation of blood vessels, bone, and connective tissue. As expression of this protein is potently induced by transforming growth factor-beta (TGFbeta), it has been hypothesized that CTGF mediates several of the downstream actions of...

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PMID: 14663501
DOI: 10.1139/o03-069

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