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Article

Autoinhibitory regulation of TrwK, an essential VirB4 ATPase in type IV secretion systems.

The Journal of biological chemistry - 13 May 2011

Peña Alejandro, Ripoll-Rozada Jorge, Zunzunegui Sandra, Cabezón Elena, de la Cruz Fernando, Arechaga Ignacio

Abstract excerpt

Type IV secretion systems (T4SS) mediate the transfer of DNA and protein substrates to target cells. TrwK, encoded by the conjugative plasmid R388, is a member of the VirB4 family, comprising the largest and most conserved proteins of T4SS. In a previous work we demonstrated that TrwK is able to hydrolyze ATP. Here, based on the structural homology of VirB4 proteins with the DNA-pumping ATPase TrwB coupling...

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Identifiers

PMID: 21454654
DOI: 10.1074/jbc.M110.208942
PMCID: PMC3089579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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