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Article

Mutation of a key residue in the type II secretion system ATPase uncouples ATP hydrolysis from protein translocation.

Molecular microbiology - 1 Jul 2007

Shiue Sheng-Jie, Chien I-Ling, Chan Nei-Li, Leu Wei-Ming, Hu Nien-Tai

Abstract excerpt

Membrane-associated ATPase constitutes an essential element common to all secretion machineries in Gram-negative bacteria. How ATP hydrolysis by these ATPases is coupled to secretion process remains unclear. Here we identified R286 as a key residue in the type II secretion system (T2SS) ATPase XpsE of Xanthomonas campestris that plays a pivotal role in coupling ATP hydrolysis to protein translocation. Mutation of...

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PMID: 17630971
DOI: 10.1111/j.1365-2958.2007.05795.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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