Article
Attenuating Effects of Pyrogallol-Phloroglucinol-6,6-Bieckol on Vascular Smooth Muscle Cell Phenotype Changes to Osteoblastic Cells and Vascular Calcification Induced by High Fat Diet.
Nutrients - 11 Sept 2020
Son Myeongjoo, Oh Seyeon, Jang Ji Tae, Park Chul-Hyun, Son Kuk Hui, Byun Kyunghee
Abstract excerpt
Advanced glycation end products/receptor for AGEs (AGEs/RAGEs) or Toll like receptor 4 (TLR4) induce vascular smooth muscle cell (VSMC) phenotype changes in osteoblast-like cells and vascular calcification. We analyzed the effect of Ecklonia cava extract (ECE) or pyrogallol-phloroglucinol-6,6-bieckol (PPB) on VSMC phenotype changes and vascular calcification prompted by a high-fat diet (HFD). HFD unregulated...
Topics
- Animals
- Benzofurans
- Diet, High-Fat
- Disease Models, Animal
- Male
- Mice
- Mice, Inbred C57BL
- Muscle, Smooth, Vascular
- Osteoblasts
- Phenotype
- Plant Extracts