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Article

Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification.

Cardiovascular research - 1 Aug 2011

Di Bartolo Belinda A, Schoppet Michael, Mattar Muhammad Z, Rachner Tilman D, Shanahan Catherine M, Kavurma Mary M

Abstract excerpt

AIMS: Osteoprotegerin (OPG) inhibits vascular calcification in vitro, and OPG(-/-) mice develop vascular calcification. Insulin-like growth factor-1 (IGF1) signalling has been implicated in vascular smooth muscle cell (VSMC) survival; however, the role of IGF1-receptor (IGF1R) expression in calcification is unclear. We sought to determine whether the protective effects of OPG in vascular calcification were...

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Source

Identifiers

PMID: 21447702
DOI: 10.1093/cvr/cvr084

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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