Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification.

doi:10.1093/cvr/cvr084

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Article

Calcium and osteoprotegerin regulate IGF1R expression to inhibit vascular calcification.

Cardiovascular research - 1 Aug 2011

Di Bartolo Belinda A, Schoppet Michael, Mattar Muhammad Z, Rachner Tilman D, Shanahan Catherine M, Kavurma Mary M

Abstract excerpt

AIMS: Osteoprotegerin (OPG) inhibits vascular calcification in vitro, and OPG(-/-) mice develop vascular calcification. Insulin-like growth factor-1 (IGF1) signalling has been implicated in vascular smooth muscle cell (VSMC) survival; however, the role of IGF1-receptor (IGF1R) expression in calcification is unclear. We sought to determine whether the protective effects of OPG in vascular calcification were...

Topics

Animals
Apoptosis
Calcinosis
Calcium
Camptothecin
Cells, Cultured
Feedback, Physiological
Gene Expression Regulation
Humans
Muscle, Smooth, Vascular
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocytes, Smooth Muscle

NF-kappa B

Osteoprotegerin

Proto-Oncogene Proteins c-bcl-2

RNA Interference

RNA, Messenger

Rats

Source

Open in PubMed

Identifiers

PMID: 21447702
DOI: 10.1093/cvr/cvr084

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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