Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.

doi:10.1093/cvr/cvp366

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.

Cardiovascular research - 1 Mar 2010

Cai Yan, Xu Ming-Jiang, Teng Xu, Zhou Ye Bo, Chen Li, Zhu Yi, Wang Xian, Tang Chao Shu, Qi Yong Fen

Abstract excerpt

AIMS: Vascular calcification (VC) is highly associated with increased morbidity and mortality in patients with advanced chronic kidney disease. Paracrine/autocrine factors such as vasoactive peptides are involved in VC development. Here, we investigated the expression of the novel peptide intermedin (IMD) in the vasculature, tested its ability to prevent VC in vivo and in vitro, and examined the mechanism...

Topics

Adrenomedullin
Animals
Aorta
Atherosclerosis
Calcinosis
Calcium-Binding Proteins
Cell Differentiation
Cell Lineage
Disease Models, Animal
Extracellular Matrix Proteins
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle, Smooth, Vascular

Neuropeptides

Nicotine

Nicotinic Agonists

Peptide Hormones

Phenotype

Rats

Source

Open in PubMed

Identifiers

PMID: 19910445
DOI: 10.1093/cvr/cvp366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein.PMID 19910445Read ↗

Intermedin1-53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho.Semantic proximity Read ↗

Vascular calcification in CKD: New insights into its mechanismsSemantic proximity Read ↗

The molecular biology and pathophysiology of vascular calcification.Semantic proximity Read ↗

Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2Semantic proximity Read ↗

Inflammatory, metabolic, and genetic mechanisms of vascular calcification.Semantic proximity Read ↗

Roles of Histone Acetylation Modifiers and Other Epigenetic Regulators in Vascular CalcificationSemantic proximity Read ↗

Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action.Semantic proximity Read ↗

The Epigenetic Landscape of Vascular Calcification: An Integrative PerspectiveSemantic proximity Read ↗

Visfatin from Adipocyte Accelerates Vascular Calcification via TLR4Semantic proximity Read ↗

Efficacy and mechanism of Shenqi Compound in Inhibiting Diabetic Vascular CalcificationSemantic proximity Read ↗

Fibroblast growth factor 21; review on its participation in vascular calcification pathology.Semantic proximity Read ↗

Bone morphogenetic proteins in vascular calcification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.