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Article

The catalytic architecture of leukotriene C4 synthase with two arginine residues.

The Journal of biological chemistry - 6 May 2011

Saino Hiromichi, Ukita Yoko, Ago Hideo, Irikura Daisuke, Nisawa Atsushi, Ueno Go, Yamamoto Masaki, Kanaoka Yoshihide, Lam Bing K, Austen K Frank, Miyano Masashi

Abstract excerpt

Leukotriene (LT) C(4) and its metabolites, LTD(4) and LTE(4), are involved in the pathobiology of bronchial asthma. LTC(4) synthase is the nuclear membrane-embedded enzyme responsible for LTC(4) biosynthesis, catalyzing the conjugation of two substrates that have considerably different water solubility; that amphipathic LTA(4) as a derivative of arachidonic acid and a water-soluble glutathione (GSH). A previous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21454538
DOI: 10.1074/jbc.M110.150177
PMCID: PMC3091245

Genes

LTA

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