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Article

Effect of ABCC2 (MRP2) transport function on erythromycin metabolism.

Clinical pharmacology and therapeutics - 1 May 2011

Franke R M, Lancaster C S, Peer C J, Gibson A A, Kosloske A M, Orwick S J, Mathijssen R H, Figg W D, Baker S D, Sparreboom A

Abstract excerpt

The macrolide antiobiotic erythromycin undergoes extensive hepatic metabolism and is commonly used as a probe for cytochrome P450 (CYP) 3A4 activity. By means of a transporter screen, erythromycin was identified as a substrate for the transporter ABCC2 (MRP2) and its murine ortholog, Abcc2. Because these proteins are highly expressed on the biliary surface of hepatocytes, we hypothesized that impaired Abcc2...

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Share to Midazolam
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21451505
DOI: 10.1038/clpt.2011.25
PMCID: PMC4519823

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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