Article
A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination.
Pharmacogenetics and genomics - 1 May 2005
Hulot Jean-Sébastien, Villard Eric, Maguy Ange, Morel Véronique, Mir Lluis, Tostivint Isabelle, William-Faltaos Demiana, Fernandez Christine, Hatem Stéphane, Deray Gilbert, Komajda Michel, Leblond Véronique, Lechat Philippe
Abstract excerpt
Human multidrug resistance protein 2 (MRP2, encoded by ABCC2) is involved in active efflux of anionic drugs such as methotrexate. MRP2 is expressed on the luminal side of hepatocytes and renal proximal tubular cells, indicating an important role in drug elimination. We postulated that loss-of-function mutations in ABCC2, which are involved in the Dubin-Johnson syndrome, may be associated with impaired...
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