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Article

Variants in FIX propeptide associated with vitamin K antagonist hypersensitivity: functional analysis and additional data confirming the common founder mutations.

Annals of hematology - 1 Jun 2018

Pezeshkpoor Behnaz, Czogalla Katrin J, Caspers Michael, Berkemeier Ann-Cristin, Liphardt Kerstin, Ghosh Suvoshree, Kellner Marco, Ulrich Silvia, Pavlova Anna, Oldenburg Johannes

Abstract excerpt

One of the most common and unwanted side effects during oral anticoagulant therapy (OAT) is bleeding complications. In rare cases, vitamin K antagonist (VKA)-related bleeding events are associated with mutations affecting the F9 propeptide at amino acid position 37 due to a substitution of alanine to either valine or threonine. Based on our actual cohort of 18 patients, we update the knowledge on this rare...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29450643
DOI: 10.1007/s00277-018-3264-2

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OAT

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Variants in FIX propeptide associated with vitamin K antagonist hypersensitivity: functional analysis and additional data confirming the common founder mutations.PMID 29450643Read ↗

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