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Article

Protein phosphatase PP6 is required for homology-directed repair of DNA double-strand breaks

1 May 2011

Abstract excerpt

DNA double-strand breaks (DSBs) are among the most lethal lesions associated with genome stability which, when destabilized, predisposes organs to cancers. DSBs are primarily fixed either with little fidelity by non-homologous end joining (NHEJ) repair or with high fidelity by homology-directed repair (HDR). The phosphorylated form of H2AX on serine 139 (γ-H2AX) is a marker of DSBs. In this study, we explored if...

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PMID: 21451261
DOI: 10.4161/cc.10.9.15479

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