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Article

Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.

Journal of the National Cancer Institute - 6 Apr 2011

Barone Ines, Brusco Lauren, Gu Guowei, Selever Jennifer, Beyer Amanda, Covington Kyle R, Tsimelzon Anna, Wang Tao, Hilsenbeck Susan G, Chamness Gary C, Andò Sebastiano, Fuqua Suzanne A W

Abstract excerpt

BACKGROUND: Estrogen receptor (ER) α is a successful therapeutic target in breast cancer, but patients eventually develop resistance to antiestrogens such as tamoxifen. METHODS: To identify genes whose expression was associated with the development of tamoxifen resistance and metastasis, we used microarrays to compare gene expression in four primary tumors from tamoxifen-treated patients whose breast cancers did...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21447808
DOI: 10.1093/jnci/djr058
PMCID: PMC3071355

Genes

MTA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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