Article
Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2003
Jiang Wen G, Watkins Gareth, Lane Jane, Cunnick Giles H, Douglas-Jones Anthony, Mokbel Kefah, Mansel Robert E
Abstract excerpt
PURPOSE: Rho family members are small GTPases that are known to regulate malignant transformation and motility of cancer cells. The activities of Rhos are regulated by molecules such as guanine nucleotide dissociation inhibitors (GDIs). This study determined the levels of expression and the distribution of Rho-A, -B, -C, and -G, and Rho-6, -7, and -8, as well as Rho-GDI-beta, and Rho-GDI-gamma, in breast cancer...
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