Use of genetically modified mouse models for evaluation of carcinogenic risk: considerations for the laboratory animal scientist.

Abstract excerpt

There has been increasing interest in the use of selected genetically modified (GM) mouse models for the testing of chemicals to determine their carcinogenic potential. GM mouse models are believed to be useful tools that offer mechanistically relevant insights for understanding and predicting the human response to chemical exposure. They have been proposed as alternatives to the traditional 2-year mouse...

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