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Article

Individual variability in the detoxification of carcinogenic arylhydroxylamines in human breast.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2011

Rhoads Keelia, Sacco James C, Drescher Nicholas, Wong Amos, Trepanier Lauren A

Abstract excerpt

Cytochrome b(5) (b5) and NADH cytochrome b(5) reductase (b5R) detoxify reactive hydroxylamine (NHOH) metabolites of known arylamine and heterocyclic amine mammary carcinogens. The aim of this study was to determine whether NHOH reduction for the prototypic arylamine 4-aminobiphenyl (4-ABP) was present in human breast and to determine whether variability in activity was associated with single nucleotide...

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Identifiers

PMID: 21447608
DOI: 10.1093/toxsci/kfr073
PMCID: PMC3098962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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