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Article

Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2008

Bains Onkar S, Takahashi Ryan H, Pfeifer Tom A, Grigliatti Thomas A, Reid Ronald E, Riggs K Wayne

Abstract excerpt

Aldo-keto reductases (AKRs) are a class of NADPH-dependent oxidoreductases that have been linked to metabolism of the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Although widely used, cardiotoxicity continues to be a serious side effect that may be linked to metabolites or reactive intermediates generated in their metabolism. In this study we examine the little known effects of nonsynonymous single...

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Identifiers

PMID: 18276838
DOI: 10.1124/dmd.107.018895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin.PMID 18276838Read ↗

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