Article
Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo.
Carcinogenesis - 1 Nov 2004
Trapasso Francesco, Yendamuri Sai, Dumon Kristoffel R, Iuliano Rodolfo, Cesari Rossano, Feig Byron, Seto Robin, Infante Luisa, Ishii Hideshi, Vecchione Andrea, During Matthew J, Croce Carlo M, Fusco Alfredo
Abstract excerpt
DEP-1/HPTPeta, a receptor-type protein tyrosine phosphatase, is a candidate tumor suppressor gene because its expression was blocked in rat and human thyroid transformed cells, and its restoration reverted their neoplastic phenotype. In addition, loss of DEP-1/HPTPeta heterozygosity has been described in mammary, lung and colon primary tumors. We now show that DEP-1/HPTPeta is drastically reduced in several cell...
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