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Article

Stomach-specific c-Myc overexpression drives gastric adenoma in mice through AKT/mammalian target of rapamycin signaling.

Bosnian journal of basic medical sciences - 1 Aug 2021

Liu Jing, Feng Wenxin, Liu Min, Rao Hanyu, Li Xiaoxue, Teng Yan, Yang Xiao, Xu Jin, Gao Weiqiang, Li Li

Abstract excerpt

Gastric cancer (GC) is one of the most common malignant cancers in the world. c-Myc, a well-known oncogene, is commonly amplified in many cancers, including gastric cancer. However, it is still not completely understood how c-Myc functions in GC. Here, we generated a stomach-specific c-Myc transgenic mouse model to investigate its role in GC. We found that overexpression of c-Myc in Atp4b+ gastric parietal cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33259779
DOI: 10.17305/bjbms.2020.4978
PMCID: PMC8292868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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