Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of functional single-nucleotide polymorphisms that affect apoptosis.

Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2005

Harris Sandra L, Gil German, Robins Harlan, Hu Wenwei, Hirshfield Kim, Bond Elisabeth, Bond Gareth, Levine Arnold J

Abstract excerpt

Human EBV-transformed B lymphocyte cell lines (LCLs) were used to measure the apoptotic response of individuals to gamma radiation. The responses form a normal distribution around a median of 35.5% apoptosis with a range of 12-58%. This heterogeneous response has a genetic basis. LCLs from Caucasian donors and African American donors form distinct distributions of apoptotic response; all of the 11 LCLs comprising...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Transformed

Share to Haplotypes

Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-mdm2

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 16260726
DOI: 10.1073/pnas.0508390102
PMCID: PMC1283473

Genes

AKT1
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of functional single-nucleotide polymorphisms that affect apoptosis.PMID 16260726Read ↗

Single-nucleotide polymorphisms in the p53 pathway.Semantic proximity Read ↗

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.Semantic proximity Read ↗

Detection of Individual Differences in Radiation-Induced Apoptosis of Peripheral Blood Lymphocytes in Normal Individuals, Ataxia Telangiectasia Homozygotes and Heterozygotes, and Breast Cancer Patients after RadiotherapySemantic proximity Read ↗

Systematic evaluation of apoptotic pathway gene polymorphisms and lung cancer risk.Semantic proximity Read ↗

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system.Semantic proximity Read ↗

Polymorphisms in key regulator genes of the intrinsic apoptosis pathway in risk and clinical presentation of diffuse large B-cell lymphoma.Semantic proximity Read ↗

Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia.Semantic proximity Read ↗

BIM Expression in Treatment-Naïve Cancers Predicts Responsiveness to Kinase InhibitorsSemantic proximity Read ↗

Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.Semantic proximity Read ↗

Gene polymorphisms, apoptotic capacity and cancer risk.Semantic proximity Read ↗

Polymorphisms in apoptosis-related genes and survival of patients with early-stage non-small-cell lung cancer.Semantic proximity Read ↗

The impact of SF3B1 mutations in CLL on the DNA-damage response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.